The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Function:
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
Subcellular Location:
Mitochondrion matrix.
Tissue Specificity:
Found almost exclusively in heart and skeletal muscle.
Similarity:
Belongs to the PDK/BCKDK protein kinase family.
Contains 1 histidine kinase domain.
SWISS:
Q15120
Gene ID:
5165
Database links:
Entrez Gene: 5165 Human
Entrez Gene: 236900 Mouse
Entrez Gene: 296849 Rat
Omim: 602526 Human
SwissProt: Q15120 Human
SwissProt: Q922H2 Mouse
Unigene: 296031 Human
Unigene: 12775 Mouse
Unigene: 18101 Rat
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