Rabbit Anti-PDLIM5 antibody

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ENH; ENH1; Enigma homolog; Enigma like LIM domain protein; Enigma like PDZ and LIM domains protein; Enigma-like PDZ and LIM domains protein; L 9; L9; LIM; PDLI5_HUMAN; PDLIM5; PDZ and LIM domain 5; PDZ and LIM domain protein 5.

Cat:

SL12601R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human PDLIM5:521-596/596

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the SLCterminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Function:
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.

Subcellular Location:
Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse > synaptosome. Cytoplasm. Detected both at presynaptic and postsynaptic sites.

Tissue Specificity:
Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.

Similarity:
Contains 3 LIM zinc-binding domains.
Contains 1 PDZ (DHR) domain.

SWISS:
Q96HC4

Gene ID:
10611

Database links:

Entrez Gene: 503621 Cow

Entrez Gene: 10611 Human

Entrez Gene: 56376 Mouse

Entrez Gene: 64353 Rat

Omim: 605904 Human

SwissProt: Q96HC4 Human

SwissProt: Q8CI51 Mouse

SwissProt: Q62920 Rat

Unigene: 96311 Human

Unigene: 117709 Mouse

Unigene: 221146 Rat

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