Rabbit Anti-phospho-PDLIM5 (Tyr251) antibody

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PDLIM5 (phospho Y251); p-PDLIM5 (phospho Y251); ENH; ENH1; Enigma homolog; Enigma like LIM domain protein; Enigma like PDZ and LIM domains protein; Enigma-like PDZ and LIM domains protein; L 9; L9; LIM; PDLI5_HUMAN; PDLIM5; PDZ and LIM domain 5

Cat:

SL12602R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human PDLIM5 around the phosphorylation site of Tyr251:ER(p-Y)TE

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the SLCterminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Function:
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.

Subcellular Location:
Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse > synaptosome. Cytoplasm. Detected both at presynaptic and postsynaptic sites.

Tissue Specificity:
Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.

Similarity:
Contains 3 LIM zinc-binding domains.
Contains 1 PDZ (DHR) domain.

SWISS:
Q96HC4

Gene ID:
10611

Database links:

Entrez Gene: 10611 Human

Omim: 605904 Human

SwissProt: Q96HC4 Human

Unigene: 96311 Human

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