The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]
Function:
Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization
Subcellular Location:
Lysosome
Tissue Specificity:
Ubiquitously expressed. Highly expressed in tumor cells.
Similarity:
Belongs to the phosphatidylethanolamine-binding protein family.
SWISS:
Q96S96
Gene ID:
157310
Database links:
Entrez Gene: 157310 Human
Omim: 612473 Human
SwissProt: Q96S96 Human
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