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Rabbit Anti-Periplakin antibody
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its SLCterminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
Function:
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.
Subcellular Location:
Cell junction > desmosome. Cytoplasm > cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments.
Tissue Specificity:
Expressed in stratified squamous epithelia and in some other epithelia.
Similarity:
Belongs to the plakin or cytolinker family.
Contains 2 plectin repeats.
Contains 4 spectrin repeats.
SWISS:
O60437
Gene ID:
5493
Database links:
Entrez Gene: 5493 Human
Entrez Gene: 19041 Mouse
Entrez Gene: 302934 Rat
Omim: 602871 Human
SwissProt: O60437 Human
SwissProt: Q9R269 Mouse
Unigene: 192233 Human
Unigene: 266875 Mouse
Unigene: 25259 Rat
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