Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008]
Function:
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity).By similarity.
Subcellular Location:
Cytoplasmic
Similarity:
In the N-terminal section; belongs to the FGAMS family.
Contains 1 glutamine amidotransferase type-1 domain.
SWISS:
O15067
Gene ID:
5198
Database links:
Entrez Gene: 5198 Human
Entrez Gene: 237823 Mouse
Omim: 602133 Human
SwissProt: O15067 Human
SwissProt: Q5SUR0 Mouse
Unigene: 573976 Human
Unigene: 340288 Mouse
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