This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Function:
Synthesis and degradation of fructose 2,6-bisphosphate.
Subunit:
Homodimer.
Similarity:
In the SLCterminal section; belongs to the phosphoglycerate mutase family.
SWISS:
Q16877
Gene ID:
5210
Database links:
Entrez Gene: 5210 Human
Entrez Gene: 270198 Mouse
Entrez Gene: 54283 Rat
Omim: 60564 Human
SwissProt: Q16877 Human
SwissProt: Q6DTY7 Mouse
SwissProt: Q9JJH5 Rat
Unigene: 476217 Human
Unigene: 249861 Mouse
Unigene: 90092 Rat
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