SNAP47 belongs to the SVAP1 family. It contains two t-SNARE coiled-coil homology domains. SNAP47 has ubiquitous tissue distribution, with particularly high levels in nervous tissue. In neurons, SNAP 47 has been shown to have widespread distribution on intracellular membranes and is enriched in synaptic vesicle fractions. In vitro, SNAP 47 can substitute for SNAP-25 in SNARE complex formation, but not as efficiently.
Function:
Plays a role in intracellular membrane fusion.
Subunit:
Forms a complex containing SNAP47, VAMP2 and STX1A (By similarity). Associates with the BLOSLC1 complex. Interacts with BLOC1S6.
Subcellular Location:
Endomembrane system. Cytoplasm; perinuclear region. Note: Appears to be exclusively membrane-bound.
Similarity:
Belongs to the SVAP1 family.
Contains 2 t-SNARE coiled-coil homology domains.
SWISS:
Q5SQN1
Gene ID:
116841
Database links:
Entrez Gene: 116841 Human
Entrez Gene: 67826 Mouse
Entrez Gene: 303183 Rat
SwissProt: Q5SQN1 Human
SwissProt: Q8R570 Mouse
SwissProt: Q6P6S0 Rat
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