The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]
Function:
May be involved in mediating calcium-activated chloride conductance.
Subcellular Location:
Cell membrane; Single-pass membrane protein. Apical cell membrane. Secreted. Note=The SLCterminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. Associated with the microvilli of non-goblet cell enterocytes in the small and large intestine. Co-localizes with CFTR.
Tissue Specificity:
Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp.
Post-translational modifications:
N-Glycosylated.
Processed at a monobasic residue to yield a larger N-terminal and a smaller SLCterminal cleavage products of 90 to 110 and 30 to 35 kDa, respectively.
Similarity:
Belongs to the CLCR family.
Contains 1 VWFA domain.
SWISS:
Q14CN2
Gene ID:
22802
Database links:
Entrez Gene: 22802 Human
Gene ID: 99663 Mouse
SwissProt: Q14CN2 Human
Unigene: 567422 Human
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