Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]
Function:
Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.
Subcellular Location:
Golgi apparatus > trans-Golgi network membrane. Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.
Similarity:
Belongs to the synaptobrevin family.
Contains 1 v-SNARE coiled-coil homology domain.
SWISS:
A2IDD8
Gene ID:
8674
Database links:
Entrez Gene: 8674 Human
Entrez Gene: 53330 Mouse
Entrez Gene: 312833 Rat
Omim: 606909 Human
SwissProt: A2IDD8 Human
SwissProt: O75379 Human
SwissProt: O7096 Mouse
Unigene: 6651 Human
Unigene: 10699 Mouse
Unigene: 105555 Rat
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