Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has SLCterminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed in many tissues.
Similarity:
Belongs to the peptidase S1 family.
Tryptase subfamily.
Contains 1 peptidase S1 domain.
SWISS:
Q9NRR2
Gene ID:
25823
Database links:
Entrez Gene: 25823 Human
Entrez Gene: 26945 Mouse
Entrez Gene: 302990 Rat
Omim: 609341 Human
SwissProt: Q9NRR2 Human
SwissProt: Q9QUL7 Mouse
Unigene: 592076 Human
Unigene: 36108 Mouse
Unigene: 163109 Rat
|
|
