Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor (Watt et al., 1998 [PubMed 9136353]; Forde et al., 2007 [PubMed 17077324]).[supplied by OMIM, Aug 2008]
Function:
Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).
Subunit:
Homodimer (isoform 4). Interacts with CXCR4.
Subcellular Location:
Secreted
Tissue Specificity:
Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.
Post-translational modifications:
Highly N- and O-glycosylated; contains sialic acid.
The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.
Similarity:
Belongs to the CD164 family.
SWISS:
Q0980
Gene ID:
8763
Database links:
Entrez Gene: 8763 Human
Omim: 603356 Human
SwissProt: Q0980 Human
Unigene: 520313 Human
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