Rabbit Anti-PLA2G1B antibody

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Group IB phospholipase A2; Group IB secretory phospholipase A2; MGC119834; MGC119835; PA21B_HUMAN; Phosphatidylcholine 2 acylhydrolase; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; Phospholipase A2 group IB (pancreas); Phospholipase

Cat:

SL12697R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human PLA2G1B:81-148/148

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Subunit:
Monomer or homodimer (By similarity). The inactive pro-form is a homotrimer.

Subcellular Location:
Secreted.

Post-translational modifications:
Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.

Similarity:
Belongs to the phospholipase A2 family.

SWISS:
P04054

Gene ID:
5319

Database links:

Entrez Gene: 5319 Human

Entrez Gene: 18778 Mouse

Omim: 172410 Human

SwissProt: P04054 Human

SwissProt: Q9Z0Y2 Mouse

Unigene: 992 Human

Unigene: 20190 Mouse

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