Rabbit Anti-Plakophilin 3 antibody

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PKP 3 ; PKP3 ; PKP3_HUMAN ; Plakophilin 3b ; Plakophilin-3 ; Plakophilin3.

Cat:

SL12703R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Plakophilin 3:631-730/797

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Function:
May play a role in junctional plaques.

Subcellular Location:
Nucleus. Cell junction > desmosome. Nuclear and associated with desmosomes.

Tissue Specificity:
Found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues.

Similarity:
Belongs to the beta-catenin family.
Contains 8 ARM repeats.

SWISS:
Q9Y446

Gene ID:
11187

Database links:

Entrez Gene: 11187 Human

Entrez Gene: 5692 Mouse

Entrez Gene: 293619 Rat

Omim: 605561 Human

SwissProt: Q9Y446 Human

SwissProt: Q9QY23 Mouse

Unigene: 534395 Human

Unigene: 350037 Mouse

Unigene: 14963 Rat

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