Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]
Function:
Actin-bundling protein in the absence of calcium.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach.
Post-translational modifications:
Phosphorylated.
Similarity:
Contains 2 actin-binding domains.
Contains 4 CH (calponin-homology) domains.
Contains 2 EF-hand domains.
SWISS:
Q14651
Gene ID:
5357
Database links:
Entrez Gene: 5357 Human
Entrez Gene: 102502 Mouse
Entrez Gene: 315926 Rat
Omim: 602734 Human
SwissProt: Q14651 Human
SwissProt: Q3V0K9 Mouse
Unigene: 203637 Human
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