Home
>
Product
>
Antibody
>
Rabbit Anti-PNPLA8 antibody
This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Function:
Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.
Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasm > perinuclear region.
Tissue Specificity:
Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.
Similarity:
Contains 1 patatin domain.
SWISS:
Q9NP80
Gene ID:
50604
Database links:
Entrez Gene: 50128 Human
Entrez Gene: 67452 Mouse
Entrez Gene: 314075 Rat
Omim: 612123 Human
SwissProt: Q9NP80 Human
SwissProt: Q8K1N1 Mouse
Unigene: 617340 Human
Unigene: 732217 Human
Unigene: 54126 Mouse
Unigene: 23073 Rat
|
|
