The protein encoded by this gene is the human homolog of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. This protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of the protein is not known, but it may contribute to mu chain transport in pre-B cells. [provided by RefSeq, Sep 2008]
Function:
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.
Tissue Specificity:
Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.
Similarity:
Belongs to the immunoglobulin superfamily.
Contains 1 Ig-like (immunoglobulin-like) domain.
SWISS:
Q9UKI3
Gene ID:
5962
Database links:
Entrez Gene: 458699 Chimpanzee
Entrez Gene: 101142156 Gorilla
Entrez Gene: 5962 Human
Entrez Gene: 100435857 Orangutan
Entrez Gene: 698694 Rhesus monkey
Omim: 605017 Human
SwissProt: Q9UKI3 Human
Unigene: 136713 Human
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