Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Function:
May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.
Subcellular Location:
Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle.
Tissue Specificity:
Ubiquitous. Expression was highest in heart and low in lung.
Similarity:
Belongs to the VPS11 family.
Contains 1 clathrin repeat.
Contains 1 RING-type zinc finger.
SWISS:
Q9H270
Gene ID:
55823
Database links:
Entrez Gene: 489374 Dog
Entrez Gene: 55823 Human
Entrez Gene: 71732 Mouse
Entrez Gene: 315600 Rat
Omim: 608549 Human
SwissProt: Q9H270 Human
SwissProt: Q91W86 Mouse
Unigene: 234282 Human
Unigene: 295013 Mouse
Unigene: 2637 Rat
|
|
