This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
Subcellular Location:
Cell membrane. Late endosome membrane.
Similarity:
Belongs to the VPS28 family.
Contains 1 VPS28 SLCterminal domain.
Contains 1 VPS28 N-terminal domain.
SWISS:
Q9UK41
Gene ID:
51160
Database links:
Entrez Gene: 618785 Cow
Entrez Gene: 607677 Dog
Entrez Gene: 47408 Fruit fly (Drosophila melanogaster)
Entrez Gene: 51160 Human
Entrez Gene: 66914 Mouse
Entrez Gene: 300052 Rat
Entrez Gene: 393562 Zebrafish
Omim: 611952 Human
SwissProt: Q3T178 Cow
SwissProt: Q9V359 Fruit fly (Drosophila melanogaster)
SwissProt: Q9UK41 Human
SwissProt: Q9D1C8 Mouse
SwissProt: B5DEN9 Rat
Unigene: 3935 Fruit fly (Drosophila melanogaster)
Unigene: 418175 Human
Unigene: 30028 Mouse
Unigene: 36912 Rat
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