VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Location:
Late endosome membrane. Probably associates with membranes. Recruited to the plasma membrane by HISLV1.
Similarity:
Belongs to the VPS37 family.
Contains 1 VPS37 SLCterminal domain.
SWISS:
A5D8V6
Gene ID:
55048
Database links:
Entrez Gene: 55048 Human
Entrez Gene: 107305 Mouse
Entrez Gene: 308178 Rat
Omim: 610038 Human
SwissProt: A5D8V6 Human
SwissProt: Q8R105 Mouse
Unigene: 523715 Human
Unigene: 19091 Mouse
Unigene: 12915 Rat
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