This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the SLCterminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Function:
Isoform 3 acts as a DNA-dependent transcriptional repressor.
Subcellular Location:
Nucleus and Nucleus. Cytoplasm.
Tissue Specificity:
Expressed strongly in testis, moderately in skeletal muscle, pancreas and prostate, and weakly in heart, placenta, liver, kidney, spleen, thymus and small intestine.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 9 C2H2-type zinc fingers.
Contains 1 SCAN box domain.
SWISS:
Q8NF99
Gene ID:
84307
Database links:
Entrez Gene: 506448 Cow
Entrez Gene: 100735295 Guinea pig
Entrez Gene: 100052677 Horse
Entrez Gene: 84307 Human
Entrez Gene: 69256 Mouse
Entrez Gene: 100519201 Pig
Entrez Gene: 100909408 Rat
Omim: 609601 Human
SwissProt: Q1LZ87 Cow
SwissProt: Q8NF99 Human
Unigene: 591061 Human
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