This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
Subcellular Location:
Endosome membrane. Cell membrane.
Tissue Specificity:
Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
Similarity:
Belongs to the STEAP family.
Contains 1 ferric oxidoreductase domain.
SWISS:
Q8NFT2
Gene ID:
261729
Database links:
Entrez Gene: 504616 Cow
Entrez Gene: 261729 Human
Entrez Gene: 74051 Mouse
Entrez Gene: 312052. Rat
Omim: 605094 Human
SwissProt: Q8NFT2 Human
SwissProt: Q8BWB6 Mouse
Unigene: 489051 Human
Unigene: 274956 Mouse
Unigene: 203614 Rat
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