This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Function:
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development.
Tissue Specificity:
Exclusively expressed in skeletal and heart muscle.
Similarity:
Belongs to the protein kinase superfamily.
CMGC Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
SWISS:
Q9UPE1
Gene ID:
26576
Database links:
Entrez Gene: 508325 Cow
Entrez Gene: 26576 Human
Entrez Gene: 56504 Mouse
Entrez Gene: 10048720 Pig
Entrez Gene: 293854 Rat
SwissProt: Q9UPE1 Human
SwissProt: Q9Z0G2 Mouse
SwissProt: B8Y466 Pig
Unigene: 104865 Human
Unigene: 111904 Mouse
Unigene: 72618 Rat
|
|
