This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Mediator complex subunit 21 family.
SWISS:
Q13503
Gene ID:
9412
Database links:
Entrez Gene: 418216 Chicken
Entrez Gene: 539496 Cow
Entrez Gene: 9412 Human
Entrez Gene: 108098 Mouse
Entrez Gene: 312849 Rat
Entrez Gene: 406732 Zebrafish
Omim: 603800 Human
SwissProt: Q2TBU8 Cow
SwissProt: Q13503 Human
SwissProt: Q9CQ39 Mouse
SwissProt: Q7ZTI5 Zebrafish
Unigene: 286145 Human
Unigene: 26212 Mouse
Unigene: 81879 Zebrafish
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