This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Mediator complex subunit 22 family.
SWISS:
Q15528
Gene ID:
6837
Database links:
Entrez Gene: 417159 Chicken
Entrez Gene: 613736 Cow
Entrez Gene: 6837 Human
Entrez Gene: 20933 Mouse
Entrez Gene: 499762 Rat
Entrez Gene: 415234 Zebrafish
Omim: 185641 Human
SwissProt: Q800L3 Chicken
SwissProt: Q5E9K2 Cow
SwissProt: Q15528 Human
SwissProt: Q62276 Mouse
SwissProt: A0JPN6 Rat
SwissProt: A5WUL3 Zebrafish
Unigene: 78354 Human
Unigene: 397932 Mouse
Unigene: 202721 Rat
Unigene: 15892 Zebrafish
|
|
