SUSD2 (Sushi Domain Containing 2) is a Protein Coding gene. Diseases associated with SUSD2 include Breast Cancer. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity and polysaccharide binding. An important paralog of this gene is MUC4.
Function:
May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).
Subcellular Location:
Membrane.
Tissue Specificity:
Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tisues (PubMed:25351403).
Similarity:
Contains 1 AMOP domain.
Contains 1 SMB (somatomedin-B) domain.
Contains 1 Sushi (CCP/SCR) domain.
Contains 1 VWFD domain.
SWISS:
Q9UGT4
Gene ID:
56241
Database links:
Entrez Gene: 56241 Human
SwissProt: Q9UGT4 Human
Unigene: 131819 Human
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