Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]
Function:
TFIID beta-specific TAFII.
Subunit:
TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the TAF13 family.
Contains 1 histone-fold domain.
SWISS:
Q15543
Gene ID:
6884
Database links:
Entrez Gene: 513065 Cow
Entrez Gene: 6884 Human
Entrez Gene: 99730 Mouse
Entrez Gene: 100172778 Orangutan
Omim: 600774 Human
SwissProt: Q148M7 Cow
SwissProt: Q15543 Human
SwissProt: P61216 Mouse
SwissProt: Q5R9W6 Orangutan
Unigene: 632426 Human
Unigene: 24431 Mouse
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