This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]
Function:
Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the SNF2/RAD54 helicase family.
Contains 8 HEAT repeats.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
SWISS:
O14981
Gene ID:
9044
Database links:
Entrez Gene: 9044 Human
Entrez Gene: 107182 Mouse
Entrez Gene: 73642 Rat
Omim: 605191 Human
SwissProt: O14981 Human
Unigene: 500526 Human
Unigene: 295062 Mouse
Unigene: 1237 Rat
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