The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Function:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the WD repeat TAF5 family.
Contains 6 WD repeats.
SWISS:
O75529
Gene ID:
27097
Database links:
Entrez Gene: 27097 Human
Entrez Gene: 102162 Mouse
Entrez Gene: 307927 Rat
SwissProt: O75529 Human
SwissProt: Q91WQ5 Mouse
Unigene: 270621 Human
Unigene: 291777 Mouse
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