Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]
Function:
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the TAF9 family.
SWISS:
Q9HBM6
Gene ID:
51616
Database links:
Entrez Gene: 538983 Cow
Entrez Gene: 51616 Human
Entrez Gene: 407786 Mouse
Entrez Gene: 171152 Rat
Omim: 300754 Human
SwissProt: Q9HBM6 Human
SwissProt: Q6NZA9 Mouse
SwissProt: Q62176 Rat
Unigene: 592248 Human
Unigene: 1988 Mouse
Unigene: 11270 Rat
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