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Home > Product > Antibody > Rabbit Anti-ZNF141 antibody
D4S90; PAPA6; pHZ-44; Zinc finger protein 141.
Cat:
SL7165R
Species Reactivity：
(predicted: Human,)
Immunogen：
KLH conjugated synthetic peptide derived from human ZNF141:151-250/471
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
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Unit:
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Product PDFs
Datasheet:


A zinc finger encoding cDNA (ZNF141) of the C2-H2/KRAB subfamily has been mapped to the 4p- (Wolf-Hirschhorn) syndrome (WHS) chromosome region. Zinc finger encoding genes would be good candidates for being involved in the multiple developmental defects associated with chromosomal aneusomy--because of their role as transcriptional regulators, their abundance in the genome and their known association with specific developmental disorders.

Function:
May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

Subcellular Location:
Nuclear.

DISEASE:
The disease is caused by mutations affecting the gene represented in this entry.
Disease description:A condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Contains 1 KRAB domain.

SWISS:
Q15928

Gene ID:
7700

Database links:

Entrez Gene: 7700 Human

Omim: 194648 Human

SwissProt: Q15928 Human

Unigene: 654355 Human



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