This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Function:
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state
Subunit:
Interacts with ERBB2, BPAG1 and ITGB4. May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin. Interacts (via SLCterminus) with DST Isoform 3 (via N-terminus).
Tissue Specificity:
Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
Similarity:
Belongs to the LAP (LRR and PDZ) protein family.
Contains 17 LRR (leucine-rich) repeats.
Contains 1 PDZ (DHR) domain.
SWISS:
Q96RT1
Gene ID:
55914
Database links:
Entrez Gene: 55914 Human
Entrez Gene: 59079 Mouse
Omim: 606944 Human
SwissProt: Q96RT1 Human
SwissProt: Q80TH2 Mouse
Unigene: 519346 Human
Unigene: 591774 Human
Unigene: 597241 Human
Unigene: 277354 Mouse
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