DAK is a 575 amino acid protein belonging to the dihydroxyacetone kinase (DAK) family. Existing as a homodimer, DAK catalyzes the formation of FAD to cyclin FMN, as well as the phosphorylation of dihydroxyacetone and splitting of ribonucleoside diphosphate-X compounds. DAK contains one DhaK domain, a DhaL domain, and is encoded by a gene located on human chromosome 11. Chromosome 11 houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Function:
Catalyzes both the phosphorylation of dihydroxyacetone and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.
Similarity:
Belongs to the dihydroxyacetone kinase (DAK) family.
Contains 1 DhaK domain.
Contains 1 DhaL domain.
SWISS:
Q3LXA3
Gene ID:
26007
Database links:
Entrez Gene: 26007 Human
Entrez Gene: 512373 Cow
SwissProt: Q58DK4 Cow
SwissProt: Q3LXA3 Human
Unigene: 6278 Human
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