Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Subunit:
Homodimer.
Subcellular Location:
Mitochondrion matrix.
Post-translational modifications:
Phosphorylation at Ser-88 appears to control the dimer-monomer transition.
Similarity:
Belongs to the LDH/MDH superfamily. MDH type 1 family.
SWISS:
P40926
Gene ID:
4191
Database links:
Entrez Gene: 4191 Human
Entrez Gene: 17448 Mouse
Entrez Gene: 81829 Rat
Omim: 154100 Human
SwissProt: P40926 Human
SwissProt: P08249 Mouse
SwissProt: P04636 Rat
Unigene: 520967 Human
Unigene: 297096 Mouse
Unigene: 1011 Rat
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