The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Tissue Specificity:
Present in scalp but not in hairless skin. Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla.
Similarity:
Belongs to the intermediate filament family.
SWISS:
Q15323
Gene ID:
3881
Database links:
Entrez Gene: 3881 Human
Entrez Gene: 16660 Mouse
Entrez Gene: 450228 Rat
Omim: 601077 Human
SwissProt: Q15323 Human
SwissProt: Q61765 Mouse
Unigene: 41696 Human
Unigene: 439673 Mouse
Unigene: 129815 Rat
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