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Rabbit Anti-ZNF769/RB associated KRAB repressor antibody
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]
Function:
May repress E2F-dependent transcription. May promote AR-dependent transcription.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 16 C2H2-type zinc fingers.
Contains 1 KRAB domain.
SWISS:
Q9NYW8
Gene ID:
57786
Database links:
Entrez Gene: 57786 Human
Entrez Gene: 57782 Mouse
Omim: 608191 Mouse
SwissProt: Q9NYW8 Human
SwissProt: Q8BQC8 Mouse
Unigene: 396178 Human
Unigene: 64419 Mouse
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