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Rabbit Anti-Desmocollin 1 + 2 antibody
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Function:
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Subunit:
.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Tissue Specificity:
Strongly expressed in epidermis, less in lymph node and tongue.
Similarity:
Contains 5 cadherin domains.
SWISS:
Q08554
Gene ID:
1823
1824
Database links:
Entrez Gene: 1823 Human
Entrez Gene: 13505 Mouse
Entrez Gene: 291759 Rat
Omim: 125643 Human
SwissProt: Q08554 Human
SwissProt: P55849 Mouse
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