The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Ubiquitously expressed but isoform 1 is the most predominant isoform.
Similarity:
Belongs to the Nudix hydrolase family. NudF subfamily.
Contains 1 nudix hydrolase domain.
SWISS:
Q9BW91
Gene ID:
53343
Database links:
Entrez Gene: 53343 Human
Entrez Gene: 74167 Mouse
Entrez Gene: 305149 Rat
Omim: 606022 Human
SwissProt: Q9BW91 Human
SwissProt: Q8BVU5 Mouse
SwissProt: Q5XIG0 Rat
Unigene: 149500 Human
Unigene: 241484 Mouse
Unigene: 22103 Rat
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