The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]
Function:
Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis.
Subcellular Location:
Endoplasmic reticulum membrane.
Tissue Specificity:
Highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder.
Similarity:
Belongs to the very long-chain fatty acids dehydratase HACD family.
SWISS:
B0YJ81
Gene ID:
9200
Database links:
Entrez Gene: 9200
Human
Entrez Gene: 30963 Mouse
Omim: 610467 Human
SwissProt: B0YJ81 Human
SwissProt:
Q9QY80 Mouse
Unigene:
114062 Human
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