Rabbit Anti-SEC24B antibody

Home > Product > Antibody > Rabbit Anti-SEC24B antibody

Protein transport protein Sec24B; SC24B_HUMAN; SEC24; SEC24 family, member B (S. cerevisiae); SEC24 related gene family, member B; SEC24-related protein B; SEC24B; secretory protein 24.

Cat:

SL4452R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human SEC24B:781-880/1286

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

prev next

Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

Subunit:
COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and SAR1. SEC24B is capable of forming heterodimers with SEC24A. Interacts with RNF139. Interacts with TMED2 and TMED10. Interacts with CNIH4 (PubMed:2885750).

Subcellular Location:
Cytoplasm. Cytoplasm > perinuclear region. Endoplasmic reticulum membrane. Golgi apparatus membrane. Golgi apparatus membrane.

Tissue Specificity:
Expressed in fibroblasts, hepatocytes, and lymphocytes.

Similarity:
Belongs to the SEC23/SEC24 family. SEC24 subfamily.

SWISS:
O95487

Gene ID:
10427

Database links:

Entrez Gene: 10427 Human

Omim: 607184 Human

SwissProt: O95487 Human

Unigene: 292472 Human

Product Feedback Wall