The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]
Function:
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
Subcellular Location:
Secreted.
Tissue Specificity:
Seminal vesicles, and to a much lesser extent, epididymis.
Post-translational modifications:
Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide.
Similarity:
Belongs to the semenogelin family.
SWISS:
Q02383
Gene ID:
1287
Database links:
Entrez Gene: 1287 Human
Entrez Gene: 20942 Mouse
Omim: 182141 Human
SwissProt: Q02383 Human
Unigene: 537218 Human
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