The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]
Function:
Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.
Similarity:
Belongs to the small GTPase superfamily. Rab family.
SWISS:
Q13637
Gene ID:
2201
Database links:
Entrez Gene: 100856634 Dog
Entrez Gene: 2201 Human
Entrez Gene: 702431 Monkey
Entrez Gene: 67844 Mouse
Entrez Gene: 365042 Rat
Omim: 612906 Human
SwissProt: Q13637 Human
SwissProt: Q9CZE3 Mouse
Unigene: 287714 Human
Unigene: 31486 Mouse
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