QRSL belongs to the amidase family. Catalytic activity: ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. There are two named isoforms.
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subunit:
Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the amidase family. GatA subfamily.
SWISS:
Q9H0R6
Gene ID:
55278
Database links:
Entrez Gene: 55278 Human
Entrez Gene: 76563 Mouse
Entrez Gene: 309911 Rat
SwissProt: Q9H0R6 Human
SwissProt: Q9CZN8 Mouse
SwissProt: Q5FWT5 Rat
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