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Rabbit Anti-RAB11FIP1 antibody
This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
Function:
A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.
Subcellular Location:
Recycling endosome. Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC) and Cytoplasmic vesicle, phagosome membrane. Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).
Tissue Specificity:
Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.
Similarity:
Contains 1 C2 domain.
Contains 1 FIP-RBD domain.
SWISS:
Q6WKZ4
Gene ID:
80223
Database links:
Entrez Gene: 80223 Human
Entrez Gene: 75767 Mouse
Entrez Gene: 498650 Rat
Omim: 608737 Human
SwissProt: Q6WKZ4 Human
SwissProt: Q9D620 Mouse
SwissProt: Q3B7T9 Rat
Unigene: 191179 Human
Unigene: 205335 Mouse
Unigene: 49288 Rat
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