Apolipoprotein SLCII (apoCII) is in found in chylomicrons (large lipoprotein particles absorbed from the gastrointestinal tract) and VLDL (large lipoproteins that are broken down to eventually form LDL). ApoCII activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells.
Function:
Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.
Subcellular Location:
Secreted.
Tissue Specificity:
Secreted in plasma.
DISEASE:
Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the apolipoprotein C2 family.
SWISS:
P02655
Gene ID:
344
Database links:
Entrez Gene: 344 Human
Omim: 608083 Human
SwissProt: P18658 Cynomolgus Monkey
SwissProt: P02655 Human
Unigene: 75615 Human
|
|
