This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes SLCterminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]
Function:
Acts as a ligand for the NKG2D receptor and mediates NK cell cytotoxicity via the receptor.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Highly expressed in colon and in a number of tumor cell lines.
Similarity:
Belongs to the MHC class I family.
SWISS:
Q6H3X3
Gene ID:
353091
Database links:
Entrez Gene: 404100 Cow
Entrez Gene: 353091 Human
Omim: 609244 Human
SwissProt: Q6H3X3 Human
Unigene: 558792 Human
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