The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Function:
May function as a nuclear transport receptor.
Subcellular Location:
Cytoplasm. Nucleus. Nucleus > nuclear pore complex.
Tissue Specificity:
Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.
Similarity:
Belongs to the exportin family.
SWISS:
Q9H2T7
Gene ID:
64901
Database links:
Entrez Gene: 739299 Chimpanzee
Entrez Gene: 529222 Cow
Entrez Gene: 479293 Dog
Entrez Gene: 64901 Human
Entrez Gene: 100526145 Pig
Entrez Gene: 303029 Rat
Omim: 606141 Human
SwissProt: Q9H2T7 Human
Unigene: 410810 Human
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