Rabbit Anti-RASGEF1B antibody

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GPIG4.

Cat:

SL21162R

Species Reactivity：

(predicted: Human,Mouse,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human RASGEF1B:1-100/473

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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RASGEF1B (RasGEF Domain Family Member 1B) is a Protein Coding gene. Diseases associated with RASGEF1B include Chromosome 4Q21 Deletion Syndrome. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGEF1C.

Function:
Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).

Subunit:
Interacts with Ras family proteins (By similarity). Interacts with CCDC124 during cytokinesis.

DISEASE:
Up-regulated in macrophages stimulated with IFNG, GPI-mucins or bacterial lipopolysaccharides (LPS).

Similarity:
Contains 1 N-terminal Ras-GEF domain.
Contains 1 Ras-GEF domain.

SWISS:
Q0VAM2

Gene ID:
153020

Database links:

Entrez Gene: 153020 Human

SwissProt: Q0VAM2 Human

Unigene: 591696 Human

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