This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.[provided by RefSeq, Dec 2008]
Function:
DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in stomach and trachea. Abundantly expressed in the apical domain of the surface epithelial cells and the deep cells in the gastric gland. Also expressed in heart, brain, lung and liver.
Similarity:
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Contains 1 STAS domain.
SWISS:
Q7LBE3
Gene ID:
115019
Database links:
Entrez Gene: 115019 Human
Entrez Gene: 64718 Mouse
Entrez Gene: 304784 Rat
Omim: 608481 Human
SwissProt: Q7LBE3 Human
SwissProt: Q8BU91 Mouse
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