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Rabbit Anti-Transition Protein 1 antibody
eRF3a is a 499 amino acid protein that belongs to the GTP-binding elongation factor family and is involved in the regulation of cell growth, specifically via control of translation termination. Human eRF3a shares 94% sequence identity with its mouse counterpart, suggesting a conserved function between species. The gene encoding eRF3a maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Function:
Translation termination in eukaryotes is governed by two proteins, belonging to the class-1 (eRF1) and class-2 (eRF3) polypeptide release factors. eRF3/GSPT1 is involved in regulation of mammalian cell growth and belongs to the GTP-binding elongation factor family (ERF3 subfamily). eRF3 catalyzes hydrolysis of GTP to GDP and inorganic phosphate in the ribosome in the absence of mRNA, tRNA, aminoacyl-tRNA and peptidyl-tRNA.
Subunit:
Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.
Subcellular Location:
Cytoplasmic.
Similarity:
Belongs to the GTP-binding elongation factor family. ERF3 subfamily.
SWISS:
P15170
Gene ID:
14852
Database links:
Entrez Gene: 14852 Mouse
Entrez Gene: 2935 Human
Omim: 139259 Human
SwissProt: P15170 Human
Unigene: 528780 Human
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